2019年

15th Winter Brain & Heart Symposium 2019, February 24,2019, Sils Maria, Switzerland

1. Yoshinori Yoshida.Generation of human pluripotent stem cell-derived mature cardiomyocytes for biomedical applications.

EHRA 2019, March 17-19, 2019, Lisbon, Portugal

1. Takashi Yoshizawa, Satoshi Shizuta, Akihiro Komasa, Yasuhiro Sasaki, Atsushi Kobori, Yutaka Furukawa, Takahiro Iseda, Junji Morita, Kenichi Hiroshima, Kenji Ando, Takeshi Kimura. A Multicenter Registry of Catheter Ablation for Atrial Fibrillation with the Second Generation Cryoballoon: From the BREAK-AF Study.

American College of Cardiology (ACC), March 16-18, 2019, New Orleans, USA

1. Kato ET, Silverman MG, Mosenzon O, Zelniker TA, Cahn A, Furtado RHM, Kuder J, Murphy SA, Bhatt DL, Leiter L, McGuire DK, Wilding JPH, Bonaca MP, Ruff CT, Desai AS, Goto S, Johansson PA, Gause-Nilsson I, Johanson P, Langkilde AM, Raz I, Sabatine M, Wiviot S. Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus Results from the DECLARE-TIMI 58 Trial.
2. Hirotoshi Watanabe, Takenori Domei, Takeshi Morimoto, Hiroki Shiomi, Masahiro Natsuaki, Toshiaki Toyota, Kensuke Takagi, Yoshiki Hata, Satoru Suwa, Mamoru Nanasato, Masanobu Ohya, Masahiro Yagi, Takafumi Yokomatsu, Mitsuru Abe, Kenji Ando, Kazushige Kadota, Ken Kozuma, Yoshihiro Morino, Yuji Ikari, Kengo Tanabe, Koichi Nakao, Kazuya Kawai, Yoshihisa Nakagawa, Takeshi Kimura, STOPDAPT-2investigators One-Month Dual Antiplatelet Therapy Followed by Clopidogrel Monotherapy versus Standard 12-Month Dual Antiplatelet Therapy with Clopidogrel After Drug-Eluting Stent Implantation: STOPDAPT-2 trial.
3. Kitai T, Miyakoshi C, Yaku H, Kato T, Morimoto T, Ozasa N, Yamamoto E, Tamaki Y, Inuzuka Y, Nagao K, Furukawa Y, Tang WH, Kimura T. Mode of Death in Heart Failure with Preserved, Mid-range and Reduced Ejection Fraction: Insights From KCHF Registry.

Xience Sierra Launch Synposium & Technology Innovation Forum, Mar. 24th, 2019, Taipei

1. Hirotoshi Watanabe, Xience Sierra in ACS Japan Experience Sharing & the What STOPDAPT-2 Trial Tells Us.

9th FAOPS Congress (Federation of the Asian and Oceanian Physiological Science), March 28-31, 2019, Kobe, Japan

1. Nishi E, Iwasaki H, Nishi K, Ohno M, Matsuda S.Nardilysin in hepatocyte regulates adaptive thermogenesis in brown adipose tissue.

CIC venture café Cambridge, April 12, 2019, Boston, USA

1. Yoshinori Yoshida.Introduction of T-CiRA iPSC-Cardiomyocytes Therapy.

TCTAP 2019, April 27-30 2019, Seoul, Korea

1. Fumiya Yoneda, Junichi Tazaki, Takeshi Kimura. Successful PCI For RCA CTO Lesion with Reverse CART Procedure.

Heart Rhythm Scientific Sessions, May 8-11, 2019, San Francisco, USA

1. Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani,Yimin Wuriyanghai, Yuta Yamamoto, Gao Jungshan, Hai Huang, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiichi Sato, Minoru Horie, Naomasa Makita, Takeshi Kimura. Modeling Overlap Syndrome Of Long QT And Brugada Syndrome Associated With CACNA1C-E1115K Which Alters Ion Selectivity With Induced Pluripotent Stem Cells.
2. Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano. Autonomic Action Potential Analyzing System Enables Accurate Interpretation and Prediction of Result for Drug Testing Using hiPSC-CMs
3. Yoshinori Yoshida.Generation of Mature Cardiomyocytes from Pluriponte Stem Cells.

Heart failure 2019, May 25-28, 2019, Athens, Greece

1. Yaku H, Kato T, Morimoto T, Inuzuka Y, Tamaki Y, Ozasa N, Yamamoto E, Kimura T. Demographics, management, and in-hospital outcomes of patients with hospitalized acute heart failure syndromes in the contemporary real clinical practice.
2. Yoshikawa Y, Tamaki Y, Yaku H, Yamamoto E, Ozasa N, Inuzuka Y, Morimoto T, Kato T, Kimura T. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in heart failure patients with mid-range and preserved ejection fraction and clinical outcomes: from the KCHF Registry.

2019 XXIII ISHR WORLD CONGRESS, June 3-6, 2019, Beijing, China

1. Koh Ono. MicroRNA in cardiovascular biology and disease.
2. Takahiro Horie, Satoshi Koyama, Takeshi Kimura, Koh Ono. The identification of differential roles of microRNA-33a and -33b during atherosclerosis progression with genetically modified mice.
3. Masahiro Kimura. Serum microRNA-122-5p reflects liver injury in patients with acute cardiac failure.

ISACB+ISVTE 2019, June 19-21, 2019, Zurich, Switzerland

1. Yoshinori Yoshida.Maturation of pluripotent stem cell-derived cardiomyocytes for biomedical applications.

ISSCR 17th Annual Meeting, June 26-29, 2019, Los Angeles, USA

1. Masayuki Umeda, Chihiro Okada, Akira Watanabe, Akifumi Kondo-Takaori, and Yoshinori Yoshida.Single cell analysis elucidates the mechanism of Cardiac and Hematopoietic differentiation from human pluripotent stem cells.

14th Pan-Pacific Continence Society Annual Meeting, July 12-14, 2019, Sydney, Australia

1. Torimoto K, Gotoh D, Iwasaki H, Iwamoto T, Morizawa Y, Hori S, Miyake M, Tanaka N, Hirayama A, Nishi E, Fujimoto K. The effects of tadalafil on bladder proteins associated with bladder function in type 1 diabetic rats.

Cardiovascular Innovations 2019, July 17-20, 2019, Denver, USA

1. Junichi Tazaki, Takeshi Kimura. Severe vascular spasm during EVT for Below the knee CLI intervention.

Basic Cardiovascular Sciences (BCVS) 2019, July 29 - August 1, 2019, Boston, USA

1. Takahiro Horie, Satoshi Koyama, Yui Miyasaka, Takeshi Kimura, Koh Ono Identification of Differential Roles of Microrna-33a and -33b During Atherosclerosis Progression with Genetically Modified Mice.
2. Masahiro Kimura. Homeobox A4 suppresses Vascular Smooth Muscle Cell Phenotypic Switching as a Novel Regulator of YAP/TEAD Transcriptional Activity
3. Hideaki Inazumi, Koichiro Kuwahara, Yoshihiro Kuwabara, Yasuaki Nakagawa, Hideyuki Kinoshita 、 Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi,Kazuwa Nakao, Takeshi Kimura. Increased Gαo expression plays a pivotal role in the progression of heart failure by impairing Ca2+ handling.

XVI European Biological Rhythms Society Congress (EBRS2019), August 25-29, 2019, Lyon, France

1. Hiraoka Y, Yoshitane H, Ohno M, Morita Y, Nunokawa R, Nishi K, Kume N, Kimura T, Fukada Y, and Nishi E. Nardilysin is a critical component of the mammalian circadian negative feedback loop.

International Congress on Obesity and Metabolic Syndrome, August 29-31, 2019, Seoul, Korea

1. Kato ET. The role of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus.
2. Kato ET. Cardiorenal benefit of SGLT2 inhibitors in patients with type 2 diabetes mellitus.

Web symposium for T2DM, August 29, 2019, Seoul, Korea

1. Kato ET. Recent T2DM updates.

Grand Round at Korea University Guro Hospital, August 29, 2019, Seoul, Korea

1. Kato ET. T2DM treatment updates.

CARE-ME symposium, August 30, 2019, Seoul, Korea

1. Kato ET. See the unseen in recent cardiovascular outcome trials of T2DM treatment.

European Society of Cardiology (ESC) Congress 2019, August 31-September 4, 2019, Paris, France

1. T Horie, S Koyama, T Kimura, K Ono. Identification of differential roles of microRNA-33a and -33b during atherosclerosis progression with genetically modified mice.
2. H Yaku, T Kato, T Morimoto, Y Inuzuka, Y Tamaki, E Yamamoto, Y Yoshikawa, N Ozasa, K Kuwahara, T Kimura. Prognostic impact of mineralocorticoid receptor antagonists in patients hospitalized for acute heart failure.
3. H Inazumi, K Kuwahara, Y Kuwabara, Y Nakagawa, H Kinoshita, K Moriuchi, H Yanagisawa, T Nishikimi, M Oya, M Yamada, T Kashihara, N Kurebayashi, M Sugihara, K Nakao, T Kimura. Increased Gao expression underlies cardiac dysfunction and lethal arrhythmias accompanied with abnormal Ca2+ handling.
4. Y Yamashita. Duration of anticoagulation in deep vein thrombosis: Guidelines vs. clinical practice.
5. Y Yamashita, T Morimoto, H Amano, T Takase, S Hiramori, K Kim, M Oi, K Murata, Y Tsuyuki, J Sakamoto, Y Yoshikawa, H Shiomi, T Makiyama, K Ono, T Kimura. Deep vein thrombosis in upper extremities: clinical characteristics, management strategies and long-term outcomes from the COMMAND VTE Registry.
6. Y Yamashita, Y Yoshikawa, T Morimoto, H Amano, T Takase, S Hiramori, K Kim, M Oi, K Murata, Y Tsuyuki, J Sakamoto, H Shiomi, T Makiyama, K Ono, T Kimura. The association of recurrence and bleeding events with mortality after venous thromboembolism: from the COMMAND VTE Registry.
7. T Yoshizawa, H Shiomi, M Tanaka, T Aizawa, S Yamagami, A Komasa, T Kimura, S Shizuta. The long-term impact of maintaining sinus rhythm on the risk for death or heart failure after catheter ablation for atrial fibrillation in a real world clinical practice.
8. Y Yoshikawa, Y Tamaki, H Yaku, E Yamamoto, N Ozasa, Y Inuzuka, T Morimoto, T Kato, T Kimura. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for heart failure patients with different left ventricular ejection fraction categories: from the KCHF Registry.
9. Y Yoshikawa, Y Yamashita, H Mabuchi, T Morimoto, H Amano, T Takase, S Hiramori, K Kim, M Oi, Y Kobayashi, M Toyofuku, T Tada, K Murata, J Sakamoto, T Kimura. The association between statin prescription, recurrent venous thromboembolism and bleeding events: from the COMMAND VTE Registry.
10. J Gao, T Makiyama, S Ohno, Y Yamamoto, Y Wuriyanghai, H Kohjitani, A Kashiwa, H Huang, K Katou, M Horie, T Kimura. Structural insights into catecholaminergic polymorphic ventricular tachycardia-associated RyR2 mutant channels using a three-dimensional in silico model.
11. Ohno M, Matsuura H., Makiyama T., Nishi K., Iwasaki H., Matsuda S., Kita T., Kimura T., and Nishi E. Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity.
12. Tamaki Y, Yaku H, Yamamoto E, Ozasa N, Inuzuka Y, Kondo H, Tamura T, Morimoto T, Nakagawa Y, Kimura T, Kato T. Impact of hyponatremia improvement on one-year outcomes in patients with acute decompensated heart failure

Meet The Specialist in ESC2019, September 2, 2019, Paris, France

1. Yugo Yamashita. Anticoagulation Therapy for VTE in the Japanese Real World -From the COMMAND VTE Registry(Tentative).

HFSA 23rd scientific meeting, September 13-16, 2019, Philadelphia, US

1. Kitai T, Kuwabara M, Morinaga T, Yaku H, Kato T, Morimoto T, Inuzuka Y, Nagao K, Tamaki Y, Yamamoto E, Ozasa N, Hisatome I, Furukawa Y, Tang WH, Kimura T. Serum Uric Acid is an Independent Predictor for All-Cause Death and Rehospitalization in Patients with Acute Decompensated Heart Failure: Insights from KCHF Registry.

APASVD 2019 Congress, September 20-22, 2019, Taipei, Taiwan.

1. Koh Ono. The identification of differential roles of microRNA-33a and -33b furing atherosclerosis progression with genetically modified mice.

the 16th International Conference of Endothelin, September 22-25, 2019, Kobe, Japan

1. Hideyuki Kinoshita, Hiromu Yanagisawa, Kenji Moriuchi, Hideaki Inazumi, Yasuaki Nakagawa, Koichiro Kuwahara, Takeshi Kimura.Macitentan for the Treatment of Pulmonary Arterial Hypertnsion with Lung Disease.

TCT2019, September 25-29, 2019, San Francisco, US

1. Takeshi Kimura. Biodegradable Polymer DES: Do Clinical Trial Data Support Claims of Superior Safety or Effectiveness?
2. Takeshi Kimura. Insights From STOP DAPT-2.
3. Hirotoshi Watanabe, Takenori Domei, Takeshi Morimoto, Hiroki Shiomi, Masahiro Natsuaki, Toshiaki Toyota, Kensuke Takagi, Yoshiki Hata, Satoru Suwa, Mamoru Nanasato, Masanobu Ohya, Masahiro Yagi, Takafumi Yokomatsu, Mitsuru Abe, Kenji Ando, Kazushige Kadota, Ken Kozuma, Yoshihiro Morino, Yuji Ikari, Kengo Tanabe, Koichi Nakao, Kazuya Kawai, Yoshihisa Nakagawa, Takeshi Kimura, STOPDAPT-2 investigators STOPDAPT-2 HBR: 1-Year Outcomes From a Randomized Trial of Clopidogrel Monotherapy vs DAPT Beginning 1 Month After PCI in Patients at High-Bleeding Risk.

11th General Meeting of the International Proteolysis Society, September 29-October 4, 2019, Mariánské Lázně, Czech Republic

1. Nishi E, Iwasaki H, Nishi K, Ohno M, Matsuda S. A metalloendopeptidase, nardilysin in hepatocyte regulates adaptive thermogenesis in brown adipose tissue.

IAEA Regional Workshop on Clinical Applications of Cardiac Multimodality Imaging in Clinical Based Setting Including PET/CT. September 30-October 4, 2019, Sapporo

1. Takao Kato. SPECT Perfusion Cases.

The 15th European Bifurcation Club (EBC) Meeting, October 18-19, 2019, Barcelona, Spain

1. Hirotoshi Watanabe. STOPDAPT-2 HBR+ Bifurcation: 1-Year Outcomes From a Randomized Trial of Clopidogrel Monotherapy vs DAPT Beginning 1 Month After PCI Post-hoc study about HBR and Bifurcation.

CCT2019 Kobe Japan, October 24-26, 2019, Kobe, Japan

1. Junichi Tazaki, Hiroki Shiomi, Hirotoshi Watanabe, Shin Watanabe, Naritatsu Saito, Takeshi Kimura. Successful Revascularization for Acute Aorto-iliac Occlusion.

12th ASIA PACIFIC HEART RHYTHM SOCIETY SCIENTIFIC SESSION (APHRS 2019), October 24-27, 2019, Bangkok, Thailand

1. Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano. Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing.
2. Takashi Yoshizawa,Satoshi Shizuta, MunekazuTanaka, Takanori Aizawa, ShintaroYamagami, Akihiro Komasa,Takeshi Kimura. Efficacy and safety of the second generation cryoballoon ablation for atrial fibrillation in patients over 75 years.
3. Takanori Aizawa. Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome.
4. Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura. Response of KCNQ1 to Adrenergic Stimulation was Impaired in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated with Long QT Syndrome.
5. Yoshinori Yoshida. Maturation of pluripotent stem cell-derived cardiomyocytes.

American Heart Association (AHA), November 16-18, 2019, Philadelphia, USA

1. Kato ET, Silverman MG, Mosenzon O, Zelniker TA, Cahn A, Furtado RHM, Kuder J, Murphy SA, Bhatt DL, Leiter L, McGuire DK, Wilding JPH, Bonaca MP, Ruff CT, Desai AS, Goto S, Johansson PA, Gause-Nilsson I, Johanson P, Langkilde AM, Raz I, Sabatine M, Wiviot S. Circulation: Innovation in Cardiovascular Science and Medicine Editor's choice.
2. Takeshi Hatani, Chikako Okubo, Yoshihiko Fujita, Kazuhisa Chonabayashi, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida. Efficient Large-Scale Purification of Human iPSC-Derived Cardiomyocytes by Synthetic microRNA Switch and Magnetic-Activated Cell Sorting.
3. Manabu Kasamoto, Shunsuke Funakoshi , Takeshi Hatani , Yoshinori Yoshida, Takeshi Kimura. The Brand-New Compound Activates Cell Cycle of Induced Pluripotent Stem Cell Derived Cardiomocytes, and Promotes Efficient Cardiac Engraftment.
4. Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura. KCNQ1 Channel Dysfunction in Human Induced Pluripotent Stem Cell- derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated with Long QT Syndrome.
5. Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Hai Huang, Takanori Aizawa, Tomohiko Imamura, Seiko Ohno, Minoru Horie, Takeshi Kimura. Morphological and electrophysiological characterization of homozygous lamin A/C knockout human induced-pluripotent stem cell-derived cardiomyocytes.
6. Nishiwaki S, Yamashita Y, Morita Y, Inoko M, Morimoto T, Amano H, Takase T, Hiramori S, Kim K, Oi M, Kato T, Kimura T. Impact of Concomitant Deep Vein Thrombosis on Clinical Outcomes in Patients With Acute Pulmonary Embolism.
7. Hata R, Yaku H, Morimoto T, Iguchi M, Inuzuka Y, Tamaki Y, Ozasa N, Yamamoto E, Kawase Y, Kadota K, Kato T, Kimura T. Long-term Prevalence And Predictors Of Fatal Arrhythmic Events After Discharge In Patients With Acute Decompensated Heart Failure With Reduced Ejection Fraction.
8. Kohei Deguchi, Kenji Miki, Shigeru Kondo, Ayaka Sakoda, Tsukasa Sugo, Taisuke Katoh, Michiyo Mochizuki, Kenichi Imahashi, Tomoyuki Nishimoto and Yoshinori Yoshida.Novel small molecules ameliorated morphological abnormalities of hypertrophic cardiomyopathy in iPS cell-derived cardiomyocytes.
9. Misato Koakutsu, Kenji Miki, Masako Sasaki, Stephanie Napier, Tomoyuki Nishimoto, Yoshinori Yoshida.Identification of a cell surface marker whichi is differentially expressed between ventricular and atrial cardiomyocytes derived from human induced-pluripotent stem cellmorphological abnormalities of hypertrophic cardiomyopathy in iPS cell-derived cardiomyocytes.

The CiRA 2019 International Symposium 2019, November 27-29, 2019, Kyoto, Japan

1. Yuya Fujiwara, Kohei Deguchi, Masako Sasaki, Yuki Naka, Kenji Miki, Tomoyuki Nishimoto, Yoshinori Yoshida.Development of hiPSCs-derived 3D heart tissue maturation method using ERRγ agonist and mechanical stress.

Joint Workshop in Medicine, University of Zurich and Kyoto University, November 27, 2019, Zurich, Switzerland

1. Koh Ono. A novel LincRNA, lionheart, prevents the exacerbation of cardiac systolic dysfunction under pressure overload.
2. Takahiro Horie. Identification of differential Roles of MicroRNA - 33a and - 33b during atherosclerosis progression with genetically modified mice.
3. Masahiro Kimura. Homeobox A4 suppresses vascular smooth muscle cell phenotypic switching as a novel regulator of YAP/TEAD pathway.
4. Yoshinori Yoshida.Generation of mature iPSC cardiomyocytes for cardiac regeneration.

International Diabetes Federation (IDF) 2019, December 2-6, 2019, Busan, Korea

1. Saeko Imai, Yuuki Saito, Shizuo Kajiyama, Takashi Miyawaki, Ayasa Nitta, Yoshitaka Hashimoto, Neiko Ozasa, Shintaro Kajiyama, Onkoo Rhee and Michiaki Fukui. Adverse effect of low-carbohydrate diet on postprandial glucose levels of following day in healthy women.

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