2014年

Keystone Symposia (Emerging Concepts and Targets in Islet Biology),April 6-11, Keystone, USA

1. Nishi K, Sato Y, Ohno M, Saijyo S, Sakamoto J, Chen P, Inagaki N, Kimura T, Nishi E: Nardilysin is a critical regulator of glucose-stimulated insulin secretion.

The 18th International Vascular Biology Meeting (IVBM), April 14-17, Kyoto, Japan

1. Ohno M, Hiraoka Y, Matsuura H, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Kita T, Kimura T, Nishi E: NRDc regulates circulatory dynamics through modulating cardiac sympathetic innervation.
2. Baba O, Horie T, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K: MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice.
3. Hakuno D, Toya T, Hamba Y, Shiraishi Y, Kujiraoka T, Adachi T: Human Plasma Amino Acid Profiling Identified the Pathophysiological Role of Arginase on Vascular Dysfunction in Systolic Heart Failure.
4. Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K: MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates Srebp1 in vivo.
5. Minami T, Kuwahara K, Kuwabara Y, Cho K, Kinoshita H, Nakagawa Y, Ueda K, Kimura T: Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice.
6. Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Tokudome T, Sone M, Kimura T, Kangawa K, Nakao K: C-type Natriuretic Peptide Derived from Vascular Endothelial Cells Contributes to the Regulation of Blood Pressure.

19th Cardiovascular Summit TCTAP 2014, April 22-25, Seoul, Korea

1. Tazaki J, Higami H, Imai M, Saito N, Kimura T: Bail-out of Acute Arterial Occlusion at Puncture Site After Closure Device Use.

International forum on pig thermogenesis and fat development, May 16, Harbin, China

1. Nishi E: Critical roles of nardilysin in the maintenance of body temperature homoeostasis.

JOINT MEETING ESH-ISH HYPERTENSION ATHENS 2014, June 13-16, Athens, Greece

1. Nishikimi T, Nakagawa Y, Kuwahara K, Kinoshita H, Kuwabara Y, Yamada C, Nakao K, Usami S, Kimura T, Nakao K: DOMINANTLY INCREASED PLASMA PROBNP, A PRECURSOR OF B-TYPE NATRIURETIC PEPTIDE, IN PATIENTS WITH RENAL FAILURE.

12th International Society for Stem Cell Research, June 18-21, Vancouver, Canada

1. Funakoshi S: What is the optimal differentiation stage of iPSC-derived cardiomyocytes for cardiac cell therapy?

Congenital & Structural Interventions Annual Congress (CSI) 2014,June 26-28, Frankfurt, Germany

1. Imai M, Watanabe S, Kimura T: Percutaneous Closure of Postoperative Residual Atrial Septal Defects with Amplatzer Closure Device.

International academy of cardiology, 19th world congress on heart disease, July 25-28, Boston, USA

1. Tanada Y, Shioi T, Kawamoto A, Okuda J, Kimura T: Branched-chain amino acids prevent heart failure in rats.

European Society of Cardiology Congress 2014, August 30-September 3, Barcelona, Spain

1. Hayano M: Cardiac Na+ Channel Gene Mutations associated with Dilated Cardiomyopathy.
2. Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Kimura T, Ono K: MicroRNA-33 deficiency leads to high fat diet- induced obesity and insulin resistance in vivo.
3. Nishiuchi S: Recapitulation of Lamin A/C-related Cardiomyopathy Using Patient-specific Induced Pluripotent Stem Cells: A Novel Splicing Mutation in the LMNA Gene.
4. Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K: MicroRNA-33a, embedded in Srebf2 gene, regulate lipogenic pathway in vivo.
5. Tazaki J, Morimoto T, Sakata R, Okabayashi H, Yamazaki F, Nishiwaki N, Mitsudo K, Kimura T: Impact of statin therapy on patients with coronary heart disease and aortic aneurysm or dissection.
6. Watanabe H, Morimoto T, Natsuaki M, Shiomi H, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Kimura T: Dual antiplatelet therapy discontinuation after coronary stenting and the risk of short-term cardiac adverse events: observation from CREDO-Kyoto Cohort-2.
7. Wuriyanghai Y: Modelling the long-QT syndrome type 1 caused by splicing mutation KCNQ1-A344A with patient-specific induced pluripotent stem-cell.
8.  Yamada C, Kuwahara K, Kuwabara Y, Kinoshita H, Nakagawa Y, Nihikimi T, Nakao K, Kimura T: Critical involvement of renin-angiotensin system for developing arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias.

The Conference on Bioactive Peptides for Cell-Cell Communication, September 10-12, Kyoto, Japan

1. Kuwahara K: Molecular pathways underlying the regulation and action of natriuretic peptides.
2. Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Yamada C, Ueshima K, Minamino N, Kimura T, Nakao K: Significance of O-glycosylation in proBNP processing.
3. Yamada C: Renin-angiotensin system promotes arrhythmogenic remodeling in mice with heart failure and sudden arrhythmic death.

9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress (MSDA), September 12-14, Kyoto, Japan

1. Ashida N, Tien DN, Kishihata M, Yoshikawa A, Hashimoto A, Sabe H, Nishi E, Kamei K, Arai H, Kita T, Kimura T, Yokode M: AMAP1 as a negative-feedback regulator of nuclear factor-kappa B.
2. Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Kita T, Kimura T, Ono K: MicroRNA-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway.
3. Nishino T, Horie T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T, Ono K: MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo.
4. Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K: Serum HDL-C decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor (Srebf1).
5. Baba O, Horie T, Ono K, Kuwabara Y, Sowa N, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T: MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice.

The 8th Otsuka Asia Atherosclerosis Conference, October 11-12, Shanghai, China

1. Ono K: Current Topics in HDL-C ~Novel regulation by microRNA-33 and implications for future therapeutic strategies~.

The 7th Asian Conference on Emergency Medicine, October 23-25, Tokyo, Japan

1. Nishiyama K: What indication should we perform primary percutaneous coronary intervention, therapeutic hypothermia, and extracorporeal CPR in patients with out-of-hospital cardiac arrest?
2. Kawano T, Nishiyama K: The restoration of lavatory systems in shelters is essential for preventing outbreaks of acute gastroenteritis.

The 7th Asia-Pacific Heart Rhythm Society (APHRS) Scientific Session, Ocrober 29-November 1, New Delhi, India

1. Hayano M: A novel SCN10A mutation identified in a patient with familial Brugada syndrome.
2. Makiyama T: Update in genetics of cardiomyopathy-Laminopathy-.
3. Makiyama T: Sudden Cardiac Death Risk Assessment Risk Stratification of Patients with Brugada Syndrome.
4. Nishiuchi S: The Relationship between the Type of Mutations in lamin A/C Gene and Cardiac Phenotype: Genetic Risk Factor for Dilated Cardiomyopathy.
5. Wuriyanghai Y: Modelling the long-QT syndrome type 1 caused by splicing mutation KCNQ1-A344A with patient-specific induced pluripotent stem-cell.

Cold Spring Harbor Meeting (Nuclear Receptors & Diseases),October 28-November 1, Cold Spring Harbor, USA

1. Ohno M, Hiraoka Y, Nishi K, Saijo S, Sakamoto J, Chen P, Makiyama T, Kita T, Matsuura H, Kimura T, Nishi E: Nardilysin controls heart rate through the regulation of sinus node automaticity.
2. Nishi E, Nishi K, Ohno M, Saijo S, Chen P, Sakamoto J, Kimura T, Kita T: Critical role of nardilysin in glucose-stimulated insulin secretion.

AASLD Liver Meeting 2014, November 7-11, Boston, USA

1. Toriguchi K, Nishi E, Hatano E, Tanabe K, Takemoto K, Seo S, Taura K, Uemoto S: Nardilysin deficiency attenuates promotion of hepatocellular carcinoma through suppressing the interleukin 6 signaling pathway.

American Heart Association 2014 Scientific Sessions, November 15-19, Chicago, USA

1. Hakuno D, Hamba Y, Toya T, Adachi T: Plasma Amino Acid Profiling Identifies Specific Amino Acid Correlations with Cardiovascular Function in Patients with Systolic Heart Failure: Highlighting the Cardio-Hepatic-Skeletal Muscle Axis.
2. Funakoshi S: Very High Engraftment, proliferation, and therapeutic potential of iPSC-derived cardiomycytes.
3. Funakoshi S: Single Cell RNA Sequencing Reveals Dynamic and Heterogeneous Changes of Transcriptome During Cardiac Differentiation in vitro.
4. Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Yokode M, Kimura T, Ono K: MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo.
5. Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Yamada C, Ueshima K, Minamino N, Kimura T, Nakao K: Role of O-glycosylation in N-terminal region of human proBNP in its processing mechanisms.
6. Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Yokode M, Kimura T, Ono K: MicroRNA-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo.
7. Nishiuchi S: Lamin A/C-Related Cardiomyopathy Specific Induced-Pluripotent Stem Cells-Derived Cardiomyocytes Stressed by Adrenergic-Stimulation Recapitulate the Aging-Related Phenotype in an Early Phase of Differentiation.
8. Nishiyama K, Ito N, Abe M, Unoki T, Endo T, Himeno H, Yamada N, Mizobuchi M, Mochizuki T, Kikuchi K, Hayashida K, Arimoto H, Orita T, Nagao K.: Severity Assessment of Brain Damage with rSO2 Monitoring for Decisions Regarding Intensive Care After Out-of-Hospital Cardiac Arrest with Presumed Cardiac Causes.
9. Wada H, Satoh-Asahara N, Akao M, Abe M, Ono K, Morimoto M, Shimatsu A, Takahashi Y, Hasegawa K: Self-rating Depression Scale Score as an Inverse and Independent Predictor of Successful Smoking Cessation with a Pharmacological Treatment for Nicotine Addiction.
10. Yamamoto Y: Electrophysiological Characteristics and Transcriptional Profiles in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes During a Long-Term Culture.
11. Yasuda H, Nishiyama K, Ito N, Arimoto H, Orita T, Murai A, Okuchi K, Anan H, Hatada T, Ishimatsu S, Tokura M, Shiga K, Kushimoto S, Hori S: Impact of Prehospital Advanced Care on Regional Brain Oxygen Saturation at Hospital Arrival and Neurological Outcomes at 90 Days in Patients with Out-of-Hospital Cardiopulmonary Arrest.

The Leipzig Interventional Course (LINC) 2015, January 27-January 30, Leipzig, Germany.

1. Tazaki J, Higami H, Nanto K, Iida O, Kimura T: Long-term outcome of endovascular aortic repair for AAA in Japanese patients.

Keystone Symposia. Mitochondria, Metabolism and Heart Failure joint with Diabetes and Metabolic Dysfunction, January 27-February 1, Santa Fe, USA.

1. Kuwabara Y: MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway.

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