2005年

日中医学研究者交流事業１０周年記念式典、4.22、北京

1. 北　徹：Oxidizes LDL and Atherosclerosis

Presidential Symposium. Sixth international conference on preventive do Iguascardiology. 5.21-25, Foz su, Brazil

1. Matsumori A: Inflammation as a fundamental risk factor.

European Heart Failure 2005, 6.11-14, Lisbon, Portugal

1. Matsumori A, Shimada T, Chapman N, Tracy S, Mason J: N-terminal pro-brain natriuretic peptide in patients

International Cardiovascular Target Therapy Forum. 6.18, Wuhan

1. Matsumori A. Up-regulation of cytokine and inflammation in myocarditis and heart failure: Pathophysiological impact.

Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies. 7.23-28, San Francisco, USA

1. Matsumori A, Chapman N, Tracy S, Mason J. Role of hepatitis C virus infection in heart failure and myocarditis.

ESC Congress 2005, 9.3-7, Stockholm, Sweden

1. Matsumori A, Tracy S, Chapman NM, Mason J. Cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with heart failure due to hepatitis C virus myocarditis.
2. Tamura T, Furukawa Y, Ono K, Kita T, Kimura T: Screening of circulating cytokines for novel biological markers in patients with congestive heart failure.
3. Ohno S, Yoshida H, Tsuji K, Makiyama T, Takenaka K, Akao M, Kita T, Horie M.. Positive arginine residue (R259) in S4-S5 linker affects activation properties of KCNQ1 potassium channel.

9th Annual Scientific Meeting, Heart Failure Society of America 9.18-21, Boca Raton, Florid, USA

1. Matsumori A, Horii T, Nakano T, Isomura T, Suma H. Free immunoglobulin light-chains as a new biomarker of heart failure.

The 1st Sino-Japan Cardiovascular Forum, 11.4, Beijing, China

1. Matsumori A, Horii T, Nakano T, Isomura T, Suma H. Free Immunoglobulin Light-chains as a New Biomarker of Heart Failure.
2. Matsumori A, Shimada T, Chapman NM, Tracy S, Mason J: Cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with heart failure due to hepatitis C virus myocarditis.

Scientific Sessions of the American Heart Association 2005, 11.13-16, Dallas, U.S.A.

1. Kita T：special sessions Phenotypic East vs West Differences.
2. Matsumori A, Shimada T, Yoshizawa H, Chapman NM, Tracy S, Mason J: N-terminal pro-brain natriuretic peptide as a biomarker of myocardial injury in patients with heart failure due to myocarditis and in health screening of individuals infected with hepatitis C virus.
3. Matsumori A, Horii T, Nakano T, Isomura T, Suma H: Increased serum concentrations of free immunoglobulin light-chains as a new clinical biomarker for the evaluation of heart failure.
4. Kishimoto C, Okabe T, Nimata M, Shioji K, Yuan Z: Cardioprotective effects of MCI-186, a novel free radical scavenger, on acute autoimmune myocarditis.
5. Kishimoto C, Yuan Z, Shioji K: Carvedilol protects against myocarditis by antioxidant actions, but not by β blocking effects.
6. Abe M, Kimura T, Nakagawa Y, Furukawa Y, Toma M, Tamura T, Taniguchi R, Kita T:Incidence of and Risk Factors for Development of Contrast-Mediated Nephropathy after Cardiac Catheterization.
7. Ehara N, Taniguchi R, Morioka S, Shizuta S, Tamura T, Nishiyama K, Furukawa Y, Nobuyoshi M, Konishi T, Nishimura K, Kinoshita M, Shiratori K, Okada Y, Teramukai S, Fukushima M, Komeda M, Kihara Y, Kita T, Kimura T for the CREDO-Kyoto Investigators:Comparison of Percutaneous Coronary Intervention (PCI) and CoronaryArtery Bypass Graft Surgery (CABG) in Patients with Multi-Vessel Coronary Artery Disease (MVD) in The Bare-Metal Stent (BMS) Era: From The Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto)
8. Iwanaga Y: "B-Type Natriuretic Peptide Strongly Reflects Diastolic Wall Stress in Patients with Chronic Heart Failure: Comparison between Systolic and Diastolic Heart Failure"
9. Matsumoto M, Akao M, Takeda T, Kita T: Real-time imaging of mitochondrial function in perfused rat hearts subjected to ischemia/reperfusion using two-photon laser scanning microscopy.
10. Ono K, Abe Y, Kawamura T, Morimoto T, Kita T, Shimatsu A, Hasegawa K: Enkephalin is predominantly expressed in the adipose tissue of diabetes with obesity and is required for differentiation into mature adipocytes.
11. Kawamura T, Morimoto T, Ono K, Kita T, Hasegawa K. ：A Natural Histone Acetyltransferase Inhibitor, Garcinol, Represses Phenylephrine-induced Hypertrophic Responses in Cardiac Myocytes.
12. Kawamura T, Miyamoto S, Ono K, Morimoto T, Wada H, Abe Y, Kano M, Kuwaki T, Nomura H, Kita T, Hasegawa K ：A continuous low-dose, but not high-dose of G-CSF therapy in cardiomyopathic hamsters with end-stage heart failure improves their survival and left ventricular systolic function.
13. Arai Y, Fujita M, Marui A, Hirose K, Huang Y, Bir SC, Tabata Y, Ikeda T: Simultaneous heparin administration with sustained-release basic fibroblast growth factor enhances angiogenesis in hypercholesterolemic mouse hindlimb ischemia.
14. Terasaki F, Shimomura H, Tsukada B, Otsuka K, Kitaura Y, Ikemoto M, Fujita M: Enhanced expression of myeloid related protein complex (MRP8/14) in multinucleated giant cells and macrophages in granulomas of patients with active cardiac sarcoidosis.
15. Yamanaka K, Doi K, Tsuneyoshi H, Yamazato A, Ueno K, Zen E, Fujita M: Multislice computed tomography accurately quantifies left atrial size and function after the maze procedure.

Angioplasty Summit 2005, 4.28-30, Seoul, Korea

1. Nakagawa Y, Kimura T, Mitsudo K, on behalf of the j-Cypher Investigators: The j-Cypher Registry, Surveillance of Sirolimus-Eluting Stent in Routine Clinical Practice in Japan. Am J of Cardiol 95 (Suppl 1) 37A, 2005
2. Tamura T, Kimura T, Mitsudo K , on behalf of the j-CYPHER Investigators Short-Term Clinical Outcome of Intracoronary Sirolimus-Eluting Stent Implantation for Bifurcation Lesions -The j-CYPHER Registry-
3. Saito N, Kimura T, Odashiro K, Toma M, Nobuyoshi M, Ueno K, Kita T, Inoue K:Treatment of Chronic Aortic Dissection with the Inoue Stent-Grafts: Short- to Medium-Term Results in 16 Patients

7th International Conference of Nuclear Cardiology, 5.8-11,Lisbon, Portugal.

1. Hosokawa R Basic Findings of BMIPP. 　Satellite symposium: Nuclear cardiology as a gatekeeper to decide the therapy.
2. Hosokawa R, Ohba M, Kambara N, Tadamura E, Kimura T, Nohara R, KitaT: The relationship between myocardial oxidative consumption and exercise tolerance in patients with chronic heart failure.
3. Kambara N, Hosokawa R, Ohba M, Saito K, Motomura H, Kanoi T, Kume N, Saji H, Kita T, Nohara R: Can intra-vascular radiation detector (IVRD) system detect unstable plaques using 18F-FDG under background activity? Simulation study

Winter Workshop of Korea Society of Interventional Cardiology, 6.14-15, Jeju, Korea

1. Nakagawa Y, Furukawa Y, Kimura T:Sirolimus-elutig stent for restenosis of left main coronary artery in Takayasu arteritis.

Practice Angioplasty Review 2005 , 6.24-25, Seoul,Korea

1. Kimura T, Morimoto T, Mitsudou K, on behalf of the j-Cypher
2. Registry Investigators:30-Day Outocome after Sirolimus-eluting Stent ( Cypher?) Implantation with Ticlopidine Anti-platelet Regimen.

Transcatheter Cardiovascular Therapeutics 2005:10.16-21,Washington,USA

1. Kimura T: Coronary Theater LIVE CASE　session Ⅲ LIVE CASE　Discussant
2. Kimura T: Perepheral Theater LIVE CASE　session Ⅳ LIVE CASE　Discussant

Taiwan Transcatheter Intervention, 12.3-4, Taipei,Taiwan

1. Kimura T: Stent Thrombosis of Drug-Eluting Stent : Overview and Insight from the j-Cypher Registry
2. Kimura T: Live Demonstration

Gordon Conference on Cell Biology of Megakaryocytes and Platelets, 3.6?11, Santa Barbara, California

1. Shirakawa R, Higashi T, Tabuchi A, Kondo H, Kawato M, Fukuda M∫, Kita T & Horiuchi H: Munc13-4 is a GTP-Rab27 binding protein regulating dense-core granule secretion in platelets.

2nd Annual Symposium of the Council on Basic Cardiovascular Sciences, 7.24-27, Keystone, U.S.A.

1. Iwanaga Y: "Down-Regulation of Cardiac Apelin System in Hypertrophied and Failing Hearts: Possible Role of Angiotensin II ? Angiotensin Type 1 Receptor System"
2. Miyamoto S, Morimoto T, Kawamura T, Ono K, Kawase Y, Kita T, Hasegawa K. ：Histone Acetyltransferase Activity of p300 Is Required for the Promotion of Left Ventricular Remodeling Following Myocardial Infarction in Adult Mice in Vivo.
3. Kawamura T, Ono K, Ehara N, Mohsen Hoseinkani, Morimoto T, Taniguchi R, Furukawa Y, Kimura T, Kita T, Suemori H, Nakatsuji N, Hasegawa K. ：Differentiation of Mouse and monkey ES cells into cardiac myocytes and cell implantation for myocardial regeneration therapy.

Heart Rhythm, , 5.4-7, New Orleans, U.S.A.

1. Ohno S, Yoshida H, Tsuji K, Takenaka K, Makiyama T, Doi T, Akao M, Kita T, Horie M. Two KCNE1 mutations in N-terminus and C-terminus result in relatively mild phenotype of long QT syndrome.

Gordon Conference on Elastin and Elastic Fiber, 7.31-8.5, New Hampshire, U.S.A.

1. Nakamura, T: Molecular mechanisms of elastic fiber organization by DANCE/ fibulin-5.

Gordon Conference on Matrix Metalloproteases, 8.28-9.2, Montana, USA

1. Nishi E, Hiraoka Y, Yoshida K, Nishimoto N: Nardilysin enhances ectodomain shedding of membrane proteins through activation of disintegrin-metalloproteases.

American Society for Cell Biology (ASCB) 45th Annual Meeting, 12.10-14, San Francisco, CA, USA.

1. Hiraoka Y, Yoshida K, and Nishi E: Nardilysin Enhances α-Secretase Activity for Amyloid Precursor Protein"

Columbia University College of Physicians and Surgeons, Department of Medicineの招聘講演、1.15, NY, USA

1. Yanagita M. Therapeutic targets of kidney diseases. Lessons from Gas6 and USAG-1.

Keystone symposium. 3.20, Keystone, USA

1. Yanagita M. USAG-1: a BMP antagonist abundantly expressed in the kidney.

American Society of Nephrology Meeting. 11.11, Philadelphia, USA

1. Yanagita M. USAG-1, a novel BMP antagonist abundantly expressed in the kidney, exacerbates renal injuries.

Harvard Medical School, Renal divisionでの招聘講演、11.14, Boston, USA

1. Yanagita M. Therapeutic targets of kidney diseases. Lessons from Gas6 and USAG-1.

Keystone Symposia, 4.3-8, Colorado, USA

1. Kawamura T, Ehara N, Mohsen Hoseinkani, Ono K, Abe Y, Morimoto T, Furukawa Y, Kita T, Suemori H, Nakatsuji N, Hasegawa K：Differentiation of mouse and monkey ES cells into cardiac myocytes and their delivery into the infracted myocardium through PTCA balloon catheters.

第1回日中心血管フォーラム、11.4,北京、中国

1. Morimoto T, Ono K, Kawamura T, Kita T, Hasegawa K ：p300-mediated Inhibition of Doxorubicin-induced Myocardial Cell Apoptosis Involves Ubiquitin-dependent p53 Degradation

The 15th European Meeting on Hypertension, 6.17-21, Milan, Italy

1. Nakano A, Lee JD, Takeishi Y, Hirai T, Kinugawa T, Fujita M: Randomized, crossover study to assess the comparative effect of valsartan and amlodipine on cardiac autonomic nervous activity in hypertensive patients.

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