2003年

Advance in the treatment and research of heart failure - Now and future, 4.26, Taipei, Taiwan

1. Matsumori A: Molecular mechanism and treatment of heart failure. Current understanding and future prespective.
2. Matsumori A: New therapeutic insights into heart failure. Role of inflammation in heart failure. Heart failure panel discussion.

12th International Congress on Cardiovascular Pharmacotherapy, 5.9, Barcelona, Spain

1. Matsumori A, Nunokawa Y, Yamaki A: A new NF-kB inhibitor suppressed production of cytokines and protected against lethal endotoxemia.

AHA Asia Pacific Scientific Forum, 6.8-10, Honolulu, Hawaii,

1. Matsumori A, Yamada Y, Sato Y: Clinical manifestation of hepatitis C virus cardiomyopathy.
2. Matsumori A, Miyazaki S, Takuo H, Obata J, Tsuyuguchi N, Nonogi H, Daikoku S, Mitsudo K, Matsunaga Y, Ohnishi T, Daikuhara Y: Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris and cerebral infarction.
3. Hata N, Yokoyama S, Ohba T, Imaizumi T, Shinada T, Yoshida H, Tokuyama K, Mizuno K, Hokusoh C, Matsumori A: Hepatocyte growth factor and cardiovascular thrombosis in patients admitted to the intensive care unit.

ACC 6th Annual Toronto International Heart Failure Summit: From Pathophysiology to Clinical Practice in the year 2003, 6.12-14, Toronto, Canada

1. Matsumori A: Role of inflammation in heart failure.
2. Matsumori A: Workshop:Myocarditis and cardiomyopathy.

Heart Failure 2003, 6.21-24, Strasbourg, France

1. Matsumori A, Nunokawa Y, Yamaki A: A new NF-kB inhibitor suppressed production of cytokines and nitric oxide, and protected against heart failure due to viral myocarditis.

ESC Congress 2003, 8.30-9.3, Vienna, Austria

1. Matsumori A, Kinoshita M, Miyazaki H, Takano H, Obata N, Tsuyuguchi N, Nonogi H, Daikoku S: Early diagnosis of thrombosis by circulating hepatocyte growth factor in patients with unstable angina pectoris and other diseases.

Heart Failure Society of America 7th Annual Scientific Meeting, 9.21-24, Las Vegas, U.S.A.

1. Kitaura-Inenaga K, Hara M, Yamamoto K, Kinoshita M, Sasayama S, Matsumori A: Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure due to viral myocarditis.
2. Hara M, Ono K, Wada H, Sasayama S, Matsumori A: Preformed angiotensin II is present in human mast cells.
3. Matsumori A, Nunokawa Y, Yamaki A: A new NF-kB inhibitor suppressed production of cytokines and protected against heart failure and lethal endotoxemia.

TRANSCATHETHER CARDIOVASCULAR THERAPEUTICS 2003, 9.16-17, Washington, D. C. USA

1. Kimura T: Oral Abstract Session: Intervention in Complex Lesions: Chronic Occlusions and Diffuse Disease, Case Reviews with the Experts: Small Vessels and Diffuse Disease: Advanced Treatment Strategies.

Complex Catheter Therapeutics 2003, 10.21-23, Hyogo, Japan

1. Kimura T: Inoue stent graft in the treatment of aotic aneurysm and aortic dissection.

Korean Circulation Society Spring Meeting, Jeju, Korea, 2003, 4,

1. Kihara Y: Pathophysiological roles of myocardial endothelin-1 Sduring transition to heart failure. (invited speaker)

XIIIth International Symposium on Atherosclerosis, Kyoto, 9.29-10.2

1. Onozawa Y, Kihara Y, Takenaka H, Kita T: Oral administration of matrix metalloproteinase inhibitor ONO-4817 blocks left ventricular remodeling in rats with salt-sensitive hypertension.
2. Kume N, Kita T: Sypmosium "Oxidized Lipoproteins and Atherosclerosis" Oxidized LDL receptors, LOX-1 and SR-PSOX, and atherogenesis.
3. Yamauchi R, Tanaka M, Minami M, Kawamoto T, Togi K, Shimaoka T, Kume N, Yonehara S, Kita T: Poster Session"Upregulation of CXCL16/SR-PSOX and recruitment of CD8+ T cells in cardiac valves during inflammatory valvular heart disease"
4. Iiyama M, Kume N, Kita T: Poster Session "Relationship of atrophic gastritis to coronary heart disease and cerebrovascular disease in Japanese population"
5. Hayashida K, Kume N, Nakagawa D, Inada T, Ueda A, Kominami G,Tanaka M, Kita T: Poster Session "Serum soluble lectin-like oxidized LDL receptor-1 (soluble LOX-1) as a novel marker for acute coronary syndrome"
6. Shibata Y, Kume N, Arai H, Harauma A, Minami M, Hayashida K, Kamei K, Hara S, Kita T, Yokode M: Poster Session "Mulberry leaf extracts inhibit expression of lectin-like oxidized LDL receptor-1 (LOX-1) in vascular endothelial cells.
7. Eto H, Miyata M, Biro S, Kume N, Minami M, Orihara K, Shirasawa T, Akasaki Y, Minagoe S, Kita T, Tei C: Poster Session"Cross-talk between angiotesin system and lectin-like oxidized LDL receptor-1 in neointima of rat carotid artery after balloon injury"
8. Abe M, Hasegawa K, Wada H, Oda T, Yoshida Y, Kita T: Statins Induce Differentiated Phenotype in Human Vascular Smooth Muscle Cells through The Inhibition of Small GTP-binding Proteins.

American Heart Association, Scientific Sessions 2003, 11.9-12, Orlando, U.S.A.

1. Onozawa Y, Kihara Y, Takenaka H, Kita T: Exogenous matrix metalloproteinase inhibitor ONO-4817 prevents LV remodeling independent of angiotensin receptor blocker telmisaran.
2. Hayashida K, Kume N, Nakagawa D, Inada T, Kimura M, Tanaka M, Kimura T, Kita T: Poster Session "Serum soluble lectin-like oxidized LDL receptor-1 (soluble LOX-1) is a novel and independent marker for acute coronary syndrome"
3. Kambara N, Ohba M, Hosokawa R, Mukai T, Kanoi T, Saito K, Kume N, Saji H, Konishi J, Nohara R: Oral Session "Detection of vulnerable plaques using a catheter-based intravascular radiation detector (IVRD)"
4. Iwai-Kanai E, Adachi S, Fujita M, Tabata Y, Hasegawa K: Aspirin acts as a protective agent against myocardial cell apoptosis via the activation of extracellular signal-regulated kinase and p300.
5. Kawamura T, Hasegawa K, Hirai M, Yoshida Y, Wada H, Morimoto T, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T: Nuclear acetylation of GATA-4 as well as of histone is involved in the differentiation of emryonic stem cells into cardiac myocytes.
6. Teruhisa Kawamura, Shoichi Miyamoto, Koji Hasegawa: Cardiac nuclear hyper-acetylation by inhibiting histone deacetylase facilitates left ventricular remodeling following myocardial infarction in adult mice in vivo.
7. Uchiyama K, Furukawa Y, Hwang MW, Hanada T, Yoshimura A, Matsumori A: T cell-specific overexpression of JAB/SOCS-1 prevents acute cardiac allograft failure in mice.
8. Higuchi H, Miyamoto T, Kinoshita M, Yamada T, Uchiyama K, Yamamoto K, Matsumori A: Mast cells play a critical role in the pathogenesis of viral myocarditis: studies on the two strains of mast cell deficient mice.

Special Lecture, Department of Molecular Pharmacology, Stanford University, Palo Alto, CA, 2003, 11.

1. Kihara Y: Pathophysiological roles of myocardial endothelin-1 during transition to heart failure. (invited speaker)

2003年韓国脂質動脈硬化学会春季学術大会, 3.7, ソウル,韓国

1. Kume N, Kita T: Oxidized LDL receptors and atherosclerosis. (Special Lecture)

WHO/ISH (BPLTTC) International Workshop, 4.10-14,Barcelona, Spain

1. Yui Y: JMIC-B

7th Research Forum on Progressive Renal Diseases, 2.8, Nagoya

1. Ono T, et al: Extracellular matrix accumulation is induced by intramesangial coagulation through mesangial factor V expression in mesangioproliferative glomerulonephritis in rats.

The World Congress of Nephrology, 6. 8-12, Berlin, Germany

1. Liu N, Ono T, Nogaki F, Muso E, Honda G, Kita T: Extracellular matrix accumulation is induced by intramesangial coagulation through factor V expression in mesangioproliferative glomerulonephritis in rats.

36th Annual Meeting of Am. Soc.Nephrol. 11.12-17, San Diego, USA

1. Tanaka M, Nomura K, Kasuno K, Liu N, Nogaki F, Arai H, Ono T, Kita T: Role of coagulation Factor Xa and PAR2 in human mesangial cell proliferation.
2. Oida E, Nogaki F, Kobayashi I, Kamata T, Ono T, Miyawaki S, Serikawa T, Yoshida H, Kita T, Muso E: Quantitative trait loci analysis (QTL) reveals a close linkage between the amino acid sequence in the hinge region and trimeric IgA dominancy in a high IgA strain (HIGA) of ddY mice.
3. Liu N, Ono T, Nogaki F, Muso E, Kita T: Developing mechanisms of interamesangial coagulation and ECM accumulation in mesangioproliferative glomerulonephhritis in rats.
4. Nomura K, Ono T, Kobayashi I, Liu N, Nogaki F, Arai H, Fukatsu A, Kita T. Role of factor Xa and effects of its inhibitor in mesangioproliferative glomerulonephritis in rats.
5. Ono T, Liu N, Makino T, Nogaki F, Nomura K, Muso E, Shimizu F, Honda G, Kita T. Mechanisms of crescent formation through mesangiolysis and local fibrin production in rat experimental mesangioproliferative glomerulonephritis.
6. Ito-Ihara T, Ono T, Kita T, Suzuki K, Muso E.　Beneficial effect of intravenous immunoglobulin for patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)- associated rapidly progressive glomerulonephritis.
7. Kasuno K, Muso E, Ono T, Takabuchi S, Yodoi J, Hirota K. Nitric oxide (NO) activates hypoxia-inducible factor 1 (HIF-1) by augmenting HIF-1α synthesis: possible mechanism allowing secure erythropoietin (EPO) production against hypoxic injury.
8. Nishida M, Kawakatsu H, Shiraishi I, Fujimoto S, Gotoh T, Urata Y, Ono T, Hamaoka K: Renal tubular regeneration by bone-marrow-derived cells in girl after bone marrow transplantation.

Collegue of Cardiology 52nd Annual Acientific Session, 3.31-4.3, Chicago, USA

1. Iwai-Kanai E, Yanazume T, Oda T, Fujita M, Adachi S, Sowa N, Hasegawa K: Aspirin protectc cardiac myocytes from apoptosis by modulating mitogen-activated protein kinases.

Scientific Conference on Molecular Mechanisms of Growth, Death and Regeneration in the Myocardium: Basic Biology and Insights into Ischemic Heart Disease and Heart Failure, 8.13-17,Snowbird Utah

1. Hasegawa K: Lys-CoA, a Specific Inhibitor of p300-Mediated Acetylation, Represses Hypertrophic Responses in Cardiac Myocytes.

The International Symposium of Cardiology Frontiers: Cardiomyopathy and Heart Failure, 10.17-18, Sapporo

1. Miyamoto S, Hasegawa K, Kawamura T, Yanazume T, Morimoto T, Kawase Y, Kita T: Overexpression of p300 Promotes Left Ventricular Endothelin-1 Expression and Remodeling Following Myocardial Infarction in Adult Mice in vivo.

Eighth International Conference on Endothelin, 11.23-26, Tsukuba

1. Kawamura T, Hasegawa K, Miyamoto S, Kita T: Cardiac nuclear hyper-acetylation by inhibiting histone deacetylase facilitates left ventricular remodeling and endothelin-1 expression following myocardial infarction in adult mice in vivo.
2. Kawamura T, Hasegawa K, Iwakura A, Nishina T, Nomoto T, Komeda M: Downregulation of endothelin-1 and alteration of apoptosis signaling following left ventricular reduction surgery in heart failure of adult rats.

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