2002年

73rd Congress of the European Atherosclerosis Society Salzburg, 7.7-10, Austria

1. Kita T: Oxidized LDL Receptors and Atherosclerosis.

Polish Society for Atherosclerosis Research, 10.24-27, Poland

1. Kita T: Oxidized LDL and Atherosclerosis.

Japan-China Joint Symposium on Geriatrics Medicine, 11.3-5, China

1. Kita T: Oxidized LDL receptors and atherogenesis.

International symposium New Aspects in Inflammatory Cardiomyopathy-Diagnosis and Therapy- 1.18-20, Berlin

1. Matsumori A: Cytokins in myocarditis and dilated cardiomyopathy.

CIVth World Congress of Cardiology, 5.5-9, Sydney, Australia

1. Matsumori A: Hepatitis C virus and cardiomyopathies .
2. Takimoto Y, Aoyama T, Yui Y: Activated TGF-β-TAK-p38MAPK pathway in non-infarcted region and its relation to ventricular remodeling after myocardial infarction in rats.
3. Takimoto Y, Aoyama T, Tanaka K, Yui Y: Augmented expression of neuronal nitric oxide synthase in the preganglionic fibers of vagal nerve decreases heart rate during acute　myocardial infarction in rats.

26th International Congress of Internal Medicine, 5.26-30, Kyoto

1. Symposium, Global Physicians Network on Myocarditis and Related Disordes. Matsumori A: Hepatitis C virus and myocarditis and cardiomyopathies.
2. Ihara I, Nogaki F, Ono T, Matsumori A, Suzuki K, Muso E: Intravenous immunoglobulin (IVIG)treatment on patients with anti-neutrophil cytoplasmic antibody (ANCA)-related glomerulonephritis.

International Congress on Cardiomyopathies and Heart Failure, 5.30-6.1, Kyoto

1. Matsumori A: Cardiomyopathies and heart failure biomolecular, infection and immune mechanism. Opening lecture.
2. Njenga K, Matsumori A, Abelmann W, Gwathmey JK: Large Animal Models of Myocarditis: Implications for Human Disease.
3. Sato Y, Yamada T, Matsumori A: Clinical features of hepatitis C virus cardiomyopathy.
4. Sato Y: Cardiac troponin T and BNP in cardiomyopathies and heart failure.
5. Yamada T, Sato Y, Matsumori A: Immunohistochemical detection of hepatitis C virus antigen in the heart tissue of patients with hepatitis C virus cardiomyopathy.
6. Taniguchi R, Sato Y, Yamada T, Higuchi H, Ooba M, Takeyasu S, Matsumori A: Measurements of serum cardiac troponin T and plasma brain natriuretic peptide in patients with heart failure.
7. Furukawa Y, Kobuke K, Yamaki A, Kinoshita M, Uchiyama K, Touma M, Nunokawa Y, Matsumori A: NF-kB inhibition reduces atherosclerotic lesion size and prevents medial smooth muscle loss in apoE-deficient mice.
8. Kinoshita M, Hara M, Furukawa Y, Matsumori A: Mast cell granules induce endothelial production of chemokines.
9. Kinoshita M, Miyamoto T, Furukawa Y, Matsumori A: Thrombosis increases the circulatory hepatocyte growth factor by degranulation of mast cells.
10. Uchiyama K, Furukawa Y, Hwang MW, Hanada T, Yoshimura A, Matsumori A: T cell-specific overexpression of JAB/SOCS-1 prevents acute cardiac allograft failure in mice.

A Brainstorming meeting on Inflammation in Myocardial and Coronary Disease.Clinical role, molecular mechanisms, diagnostic and therapeutic implications. 10.9-12, Milan, Italy

1. Matsumori A: Emerging roles of inflammatory mediators in cardiomyopathies.
2. Matsumori A: A novel NF-kB inhibitor for the treatment of inflammation in myocardial diseases and atherosclerosis.

Two Days in Cardiology, 12.7-9, Hua Hin, Thailand

1. Matsumori A: Molecular mechanism of heart failure.
2. Matsumori A: Cytokines and congestive heart failure. Current understanding and clinical implication.

The 75th Scientific Sessions of the American Heart Association, 11.17-20, Chicago, U.S.A.

1. Yamada T, Sato Y, Matsumori A: Immunohistochemical detection of hepatitis C virus antigen in the heart tissue of patients with hepatitis C virus cardiomyopathy.
2. Kinoshita M, Okada M, Hara M, Furukawa Y, Matsumori A: Mast Cell Tryptase in mast cell granules enhances the production of chemokines in human endothelial cells.
3. Furukawa Y, Kobuke K, Kinoshita M, Uchiyama K, Touma M, Matsumori A: NF-kB inhibition reduces pro-Inflammatory molecule expression and attenuates atherosclerosis in apoE-/- mice.
4. Yamamoto K, Shioi T, Miyamoto T, Matsumori A: Reduced virus-induced myocardial injury in angiotensin II type1a receptor knockout mice.
5. Onozawa Y, Yoneda T, Takenaka H, Aoyama T, Kihara Y: Exogenous MMP inhibitor ONO-4817. Blocks transition from hypertrophy of heart failure / LV remodeling in rats with salt-sensitive hypertension.
6. Abe M, Wada H, Oda T, Hasegawa K: Simvastatin Activates Zinc Finger Transcription Factor GATA-6 and induces Differentiated Phenotype inhuman Vascular Smooth Muscle Cells.
7. Hirai M, Wada H, Yanazume T, Kawamura T, Hasegawa K : FOG-2 Competes with GATA-4 for a transcriptional coactivator, p300, and suppresses hypertrophic responses in cardiac myocytes.
8. Yanazume T, Morimoto T, Wada H, Kawamura T, Kawase Y, Hasegawa K: Cardiac nuclear acetylation by p300 is involved in mycyte grewth with decompensated heart failure.
9. Kawamura T, Iwai-Kanai E, Yanazume T, Ehara N, Hasegawa K: p300 controls the transcription of the Bcl-2 gene and associates with calcineurin-dependent signaling during the protection against myocardial cell apoptosis.
10. Ehara N, Kawamura T, Iwai-Kanai E, Abe M, Hasegawa K: Activation of peroxisome proliferator-activated receptor in cardiac myocytes impairs NFATc1-depenent Bc-2 tranccription and antagonizes the protective effects of endothelin-1 against Apoptosis.
11. Hosokawa R, Nohara R, Masuda D, Kataoka K, Hirai T, Kambara N, Tadamura E, Konishi J, Sasayama S: Predictive values for the functional improvement of β-blockers therapy in patients with chronic heart failure - comparison among C-11 acetate, I-123 MIBG, and natriuretic peptides -
12. Shioji K, Kishimoto C, Yuan Z: Immunoglobulin suppressed adoptively transferred autoimmune myocarditis in severe combined immunodeficient mice. A novel suppressive effect of immunoglobulin on self-reactive T cells.
13. Shioji K, Kishimoto C, Yuan Z, Nakamura H, Masutani H, Yodoi J: Thioredoxin-1 transgenic mice attenuates adriamycin-induced cardiotoxicity. A novel redox modulating therapy against adriamycin-induced cardiotoxicity.
14. Yuan Z, Kishimoto C, Shioji K, Sano H, Xu Y, Yokode M: Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E knockout mice via the Fc portion.
15. Mitsuke Y, Lee JD, Shimizu H, Ueda T, Kishimoto C, Yodoi J: Elevated levels of serum thioredoxin/adult T-cell leukemia derived factor may reflect disease severity of patients with chronic congestive heart failure.
16. Shinoda E, Yui Y, Kanmatuse K, Hirayama A, Nonogi H, Kodama K, Sumiyoshi T, Hosoda S, and Kawai C: Nifedipine retard prevents the progression of atherosclerotic coronary lesions in hypertensive patients with coronary artery diseases, American
17. Fujita M, Mizuno K, Ho M, Miwa K: Sarpogrelate, an antagonist of 5-HT2A receptor, treatment reduces restenosis after coronary stenting.
18. Miwa S, Saito M, Yamazaki K, Toyokuni S, Hyon SH, Fujita M, Komeda M: A novel method of "preparative" myocardial protection using green tea polyphenol in oral uptake.
19. Takimoto Y, Aoyama T, Iwanaga Y, Kihara Y, Onozawa: The role of TGF-β1-TAK-p38MAPK pathway in ventricular hypertrophy inrat hypertensive model.
20. Onozawa Y, Yoneda T，Takenaka H, Aoyama T，Kihara Y: Oral administration of MMP inhibitor ONO-4817 blocks transition from hypertrophy to heart faulure/ LV remodeling in rats with salt-sensitive hypertension.

12th International Vascular Biology Meeting, 5.12-16, Karuizawa

1. Furukawa Y, Kobuke K, Yamaki A, Nunokawa Y, Matsumori A: Inhibition of NF-kB activation attenuates atherosclerosis in apolipoprotein E-deficient mice.
2. Abe M, Wada H, Yanazume T, Kawamura T, Hasegawa K : GATA-6 is involved in PPARγ-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
3. Wada H, Abe M, Hasegawa K: acetylation of GATA-6 by p300 and PCAF is involved in smooth muscle-specific transcription.

The 51st Annual Scientific Sessions, American College of Cardiology, 3.17-20, Atlanta

1. Takenaka H, Kihara Y, Inagaki K, Yoneda T: A cardioprotective agent, JTV519, inhibits apoptotic cell death of post-ischemic reperfused myocardium through dPKC-mediated ERK activation.
2. Miyamoto S, Ikemoto M, Hasegawa K, Nagaya N, Tamaki S, Miwa K, Fujita M: Increased serum levels of macrophage migration inhibitory factor-related protein is a sensitive marker for acute coronary syndrome in patients with coronary artery disease.

Special Lecture, Department of Molecular Pharmacology, Stanford University, 11.12, Palo Alto

1. Kihara Y: Factors that make the heart failing. Differential roles of endothelin-1 versus angiotensin II during transition from hypertrophy to heart failure.

Keystone Symposia, 2.13-18, Keystone, Colorado, USA

1. Iwai ?Kanai E, Adachi S, Kakita T, Hasegawa K: Endothelin-1 -mediated protection against hydrogen perioxide (H2O2)induced myocardial cell apoptosis occurs at the mitochondrial level.
2. Hasegawa K, Wada H. Morimoto T, Yanazume T, Iida M, Heike T, Nakahata T: Acetylation of GATA-4 by p300 is involved in the activation of cardiac-specific transcription during differentiation of embryonic stem cells.

Weinstein Cardiovascular Development Conference, 5.16-18, Huntsman Cancer Institute, Univeristy of Utah Campus, Salt Lake City

1. Hirai M, Wada H, Yanazume T, Hasegawa K: nuclear acetylation by p300 is involved in differentiation of embryonic stem cells into cardiac myosytes.

Advances in the Molecular and Cellular Mechanisms of Heart Failure, American Heart Association, 8.21-25, Snowbird Conference Center Snowbird, Utah

1. Hasegawa K, Wada H, Morimoto T, Yanazume T, Iida M, Heike T, Nakahata T: Acetylation of GATA-4by p300 is involved in the activation of cardiacspecific transcription during differentiation of embryonic stem cells.

5th Annual meeting of the tissue engineereing society international, 12.8-10, Kobe

1. Iwai-Kanai E, Tambara K, Sakaguchi G, Sakakibara Y, Ozeki M, Yamamoto M,Komeda M, Tabata Y: Epicardial controlled-release of hepatocyte growth factor improves cardiac function in?a rat model of dilated cardiomyopathy.

The 49th Annual Meeting of the Society of Nuclear Medicine, 6.15-19, Los Angeles

1. Hosokawa R, Nohara R, Hirai T, Kataoka K, Masuda D, Sasayama S: Predictive values for the effectiveness of β-blockers therapy in patients with chronic heart failure. -123I-MIBG versus　endogenous cardiac natriuretic peptides-

6th Research forum on progressive renal diseases, 2.9, Nagoya

1. Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E: hepatitis C virus-associated tubulointerstitial nephritis.

4th International symposium on podocyte biology, 9.19-20, Niigata

1. Ono T, Liu N, Makino T, Nogaki F, Muso E, Honda G, Kita T: factor V expression in the development of crescents formation in rat experimental mesangioproliferative glomerulonephritis.

ASN, 10.30-11.4, Philadelphia

1. Tanaka M, Kasuno K, Liu N, Kusano H, Nogaki F, Ono T: The mitogenic stimulus of coagulation factor Xa and the anti-proliferative effects of its inhibitor on cultured mesangial cells.
2. Nomura K, Ono T, Kobayashi I, Liu N, Nogaki F: Effects of factor Xa inhibitor on rat experimental mesangioproliferative glomerulonephritis.
3. Ito-Ihara T, Ishida-Okawara A, Muso E, Ono T: Role of activated neutrophils in spontaneously crescentic glomerulonephritis forming (SCG/Kj)mice.
4. Nogaki F, Oida E, Kobayashi I, Nomura K, Miyawaki S, Ono T, Yoshida H, Muso E: Genetic locus of hyperserum IgA: quantitative trait loci (QTL)analysis in high serum IgA ddY (HIGA)mice.
5. Kobayashi I, Nogaki F, Kusano H, Ono T, Miyawaki S, Yoshida H, Muso E: Role of nitric oxide on the crescent formation in a high IgA strain of ddY (HIGA)mice treated with Interleukin-12.
6. Watanabe H, Uno K, Ono T, Muso E: Dynamism of serum TGF-β and autoantibodies against oxidized-LDL were correlated with beneficial effect of LDL apheresis (LDL-A)on steroid resistant　nephrotic syndrome through amelioration of the suppressed IFN-γ production capacity (PC)of peripheral blood stimulated by interleukin12 (IL-12)
7. Liu N, Ono T, Makino T, Nogaki F, Muso E, Honda G: Extracellular matrix accumulation through mesangial factor V expression and up-regulated TGF-beta and CTGF expression in rats mesangioproliferative glomerulonephritis.
8. Oida E, Nogaki F, Kusano H, Kobayashi I, Kamata T, Ono T, Miyawaki S, Yoshida H Muso E: Quantitative trait loci (QTL)analysis of polymeric IgA in a high IgA strain of ddY (HIGA)mice, an inbred model of IgA nephropathy.

The 15th Congress of the Cardiovascular System Dynamics Society, 10.13-16, Sendai

1. Miyamoto S, Ikemoto M, Naruko T, Itoh A, Ueda M, Hasegawa K, Fujita M: Infiltrated neutrophils and macrophages in coronary vulnerable plaques of unstable angina markedly express myeloid related protein.

XXV ESC, 8.31-9.4, Berlin

1. Takimoto Y, Aoyama T, Yui Y: Activated TGF-β1-TAK-p38MAPK pathway in spared myocardium and its relation to ventricular remodeling after myocardial infarction in rats.

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