2001年

1. Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T. Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice. Science 291: 319-322.
2. Matsumori A, Sasayama S. The role of inflammatory mediators in the failing heart: Immunomodulation of cytokines in experimental models of heart failure. Heart Fail Rev 6: 129-136.
3. Sato Y, Yamada T, Taniguchi R, Nagai K, Makimura T, Okada H, Kataoka K, Ito H, Matsumori A, Sasayama S, Takatsu Y. Persistently increased serum concentrations of cardiac troponin T in patients with idiopathic dilated cardiomyopathy are predictive of adverse outcomes. Circulation 103: 369-374.
4. Matsumori A. Insights into the pathophysiology of heart failure based on a new concept. Asian Med J 44: 36-41.
5. Matsumori A. Hepatitis C virus and cardiomyopathy. Intern Med 40: 78-79.
6. Matsumori A. 5. Clinical of hepatitis: myocardial diseases, nephritis, and vasculitis associated with hepatitis virus. Intern Med 40: 182-184.
7. Miyamoto T, Matsumori A, Hwang MW, Nishio R, Ito H, Sasayama S. Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis. J Am Coll Cardiol 37: 1713-1718.
8. Matsumori A. Hepatitis C virus infection and cardiomyopathy. Newsletter of the Scientific Council on Cardiomyopathies, World Heart Federation, pp. 11-12.
9. Shioi T, Matsumori A, Kakio T, Kihara Y, Sasayama S. Proinflammatory cytokine inhibitor prolongs the survival of rats with heart failure induced by pressure overload. Jpn Circ J 65: 584-585.
10. Nakano A, Matsumori A, Kawamoto S, Tahara H, Yamato E, Sasayama S, Miyazaki J. Cytokine gene therapy for myocrditis by in vivo electroporation. Hum Gene Ther 12: 1289-1297.
11. Hwang MW, Matsumori A, Furukawa Y, Ono K, Okada M, Iwasaki A, Hara M, Miyamoro T, Touma M, Sasayama S. Neutralization of interleukin-1 b in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling. J Am Coll Cardiol 38: 1546-1553.
12. Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up- regulated after vascular injury. J Biol Chem 276: 34105-34114.
13. Furukawa Y, Kobuke K, Matsumori A. Role of cytokines in autoimmune myocarditis and cardiomyopathy. Autoimmunitiy 34: 165-168.
14. Makino T, Nakamura T, Ono T, Muso E, Honda G: Suppressive effects of Perilla frutescens on mesangioproliferative glomerulonephritis in rats. Biol Pharm Bull 24: 172-175.
15. Ono T, Liu N, Kasuno K, Kusano H, Nogaki F, Kamata T, Suyama K, Muso E, Sasayama S: Coagulation process proceeds on cultured human mesangial cells via expression of factor V. Kidney Int 60:1009-1017.
16. Makino T, Ito M, Kiuchi F, Ono T, Muso E, Honda G: Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cells and quantitative analysis of its active constituents. Planta Medica 67:24-28.
17. Nogaki F, Muso E, Yashiro M, Kasuno K, Kamata T, Ono T, Sasayama S : Direct effect of simvastain on proliferation and matrix accumulation in cultured murine mesangial cells. Clin Exp Nephrol 5:85-89.
18. Tanaka M, Ono T, Takeda T, Watanabe H, Muso E, Sasayama S: A case of Candida peritonitis followed by mediastinitis after esophageal perforation in a peritoneal dialysis patient. Peritoneal Dialysis International 21:316-322.
19. Kusano H, Miyawaki S, Yoshida H, Ono T, Muso E, Sasayama S: Heminephrectomy causes the progression glomerulosclerosis and apoptosis in high IgA strain of ddY (HIGA)mice. Nephrology 6 (Suppl.)A4.
20. Ono T, Liu N, Kusano H, Nogaki F, Suyama K, Muso E, Sasayama S: The mechanisms of intramesangial coagulation in IgA nephropathy, and the relationship to factor V expression. Nephrology 6 (Suppl.)A13.
21. Muso E, Mune M, Fujii Y, Imai E , Ueda N, Hatta K, Imada A, Takemura T, Miki S, Kuwahara T, Takamitsu Y, Tsubakihara Y, The Kansai FGS LDL Apheresis Treatment (K-FLAT)Study Group: Significantly Rapid Relief from Steroid-Resistant Nephrotic Syndrome by LDL Apheresis Compared with Steroid Monotherapy. Nephron 89:408-415.
22. Liu N, Ono T, Kawamura T, Kobayashi I, Muso E, Sasayama S : Preeclamptic nephropathy associated with membranous nephropathy. Clin Exp Nephrol 5:268-271.
23. Hosokawa R, Nohara R, Fujibayashi Y, Hirai T, Fujita M, Magata Y, Tadamura E, Konishi J, Sasayama S: Myocardial metabolism of 123I-BMIPP during low-flow ischemia in an experimental model - comparison with myocardial blood flow and 18F-FDG. Eur J Nucl Med, 28:1630-0639.
24. Kataoka K, Nohara R, Hosokawa R, Hirai T, Okuda K, Chen L, Fujibayashi Y, Fujita M, Konishi J, Sasayama S: Myocardial lipid metabolism in compensated and advanced stages of heart failure - Evaluation by canine pacing model with BMIPP. J Nucl Med, 42:124-129.
25. Masuda D, Nohara R, Hirai T, Kataoka K, Chen L, Hosokawa R, Inubushi M, Tadamura E, Fujita M, Sasayama S: Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable angina - Evaluation by 13N-ammonia positron emission tomography. Eur Heart J, 22:1451-1458.
26. Yoshida H, Horie M, Otani H, Kawashima T, Onishi Y, Sasayama S. Bradycardia-induced long QT syndrome caused by a de novo missense mutation in the S2-S3 inner loop of HERG. Am J Med Genet 98: 348-352.
27. Yamashita F, Horie M, Kubota T, Yoshida H, Yumoto Y, Kobori A, Ninomiya T, Kono Y, Haruna T, Tsuji K, Washizuka T, Takano M, Otani H, Sasayama S, Aizawa Y. Characterization and subcellular localization of KCNQ1 with a heterozygous mutation in the C-terminus. J Mol Cell Cardiol 33: 197-207.
28. Horie M, Mizuno N, Tsuji T, Ishida-Takahasi A, Haruna T, Ishida H, Seino Y, Sasayama S. Disopyramide and its metabolite block ATP-sensitive K+ channels in clonal pancreatic β-cells and enhance insulin release. Cardiovasc Drug Ther 15: 31-39.
29. The Research Group for Antiarrhythmic Drug Therapy. Cost-effectiveness of antiarrhythmic drugs for prevention of thromboembolism in patients with paroxysmal atrial fibrillation. Jpn Circ J 65; No.9: 765-768.
30. Makita T, Horie M, Xie L-H, Ai T, Okada Y, Sasayama S. Agonist-independent modulation of L-type Ca Currents by basal Gs protein activities in single guinea pig ventricular myocytes. Heart Vessels 15: 233-239.
31. Kubota T, Horie M, Takano M, Yoshida H, Takenaka K, Watanabe E, Tsuchiya T, Otani H, Sasayama S. Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias. J Cardiovasc Electr 12：1223-1229.
32. Takeuchi Y, Kihara Y, Inagaki K, Yoneda T, Sasayama S. Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart. Circulation, 103:1557-1763.
33. Hayashida W, Kihara Y, Yasaka A, Inagaki K, Iwanaga Y, Sasayama S. Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat hearts. J. Mol. Cell Cardiol , 33:733-744.
34. Iwanaga Y, Kihara Y, Inagaki K, Onozawa Y, Yoneda T, Kataoka K, Sasayama S. Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure. Circulation, 104:606-612.
35. Yoneda T, Kihara Y, Inagaki K, Hayashida W, Ohkusa T, Iwanaga Y, Shioi T, Inoko M, Ueyama T, Hisamatsu Y, Fujita M, Matsumori A, Matsuzaki M, Sasayama S. Discordant alteration of calcium regulatory proteins of the sarcoplasmic reticulum and their functions in the ventricular myocardium during the transition from established hypertrophy to failure. Life Sci 70:143-157.
36. Iwai-Kanai E, Hasegawa K, Sawamura T, Fujita M, Yanazume T, Toyokuni S, Adachi S, Kihara Y, Sasayama S. Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes. Circulation 104: 2948-2954.
37. Yuasa S, Nishina T, Nishimura K, Miwa S, Ikeda T, Hanyu M, Fujioka Y, Kihara Y, Sasayama S, Komeda M. A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy. J Cardiac Surg . 16:40-47.
38. Fujita M, Komeda M, Hasegawa K, Kihara Y, Nohara R, Sasayama S. Pericardail fluid as a new material for clinical heart research. Int J Cardiol, 77:113-118.
39. Hasegawa K, Iwai-Kanai E, Sasayama S. Neurohormonal regulation of myocardial cell apoptosis in the development of heart failure. J Cell Physiol ;186:11-18
40. Fujita M, Komeda M, Hasegawa K, Kihara Y, Nohara R, Sasayama S. Pericardial fluid as a new material for clinical heart research. Int J Cardiol ; 77:113-118
41. Iwakura A, Fujita M, Hasegawa K, Toyokuni S, Sawamura T, Nohara R, Sasayama S, Komeda M. Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptosis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway. J Mol Cell Cardiol ; 33:419-430
42. Kakita, T, Hasegawa K, Iwai-Kanai E, Adachi S, Morimoto T, Wada H, Kawamura T, Yanazume T, Sasayama S. Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes. Circ Res ; 88:1239-1246
43. Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Wada H, Yanazume T, Sasayama S. Calcineurin-GATA4 pathway is involved in b-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes. J Biol Chem ; 276:34983-34989
44. Hasegawa K, Iwai-Kanai E, Sasayama S. Differential Regulation of Myocardial Cell Apoptosis by α-and β-Adrenergic Pathways. Proceedings of the 9th International Catecholamine symposium.
45. Takimoto Y, Aoyama T. Response to the letter from Dr. Brady. Int. J. Cardiol. Vol.79:309.
46. Kishimoto C, Takada H, Kawamata H, Umetake M, Ochiai H: Immunoglobulin treatment prevents congestive heart failure in murine encephalomyocarditis viral myocarditis associated with reduction of inflammatory cytokines. J Pharmcol Exp Ther 299:645-651.
47. Kanda H, Nohara R, Hasegawa K, Kishimoto C, Sasayama S: A nuclear complex containing PPARα/RXRα is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function. Heart Vessels 15:191-196.
48. Kishimoto C, Hiraoka Y, Takada H: T cell mediated immune response enhances the severity of myocarditis in secondary cardiotropic virus infection in mice. Basic Res Cardiol 96:439-445.
49. Shioji K, Kishimoto C, Sasayama S: Fc receptor-mediated inhibitory effect of immunoglobulin therapy on autoimmune giant cell myocarditis. Concominant suppression of the expression of dendric cells. Circ Res 89 : 540-546.
50. Kishimoto C, Shioji K, Nakamura H, Nakayama Y, Yodoi J, Sasayama S : Serum thioredoxin (TRX)levels in patients with heart failure. Jpn Circ J 65 : 491-494.
51. Miyamoto M, Kishimoto C, Shioji K, Nakamura H, Toyokuni S, Nakayama Y, Kita M, Yodoi J, Sasayama S : Difference of thioredoxin expression in viral myocarditis in inbred strains of mice. Jpn Circ J 65 : 561-564.
52. Hiraoka Y, Kishimoto C, Takada H, Ochiai H : Oral administration of L-arginine prevents congestive heart failure in murine viral myocarditis. J Cardiovasc Pharmacol 36 : 555-561.
53. Yasaka A, Hayashida W. Alterations of load-induced p38 MAP kinase activation in failing rat hearts. Biochem Biophys Res Commun. 2001; 285:503-507.
54. Davie L. Lehtonen JY, Hayashida W, Dzau VJ, Horiuch, M. Intracellular third loops in AT1 and AT2 receptors determine subtype specificity. Life Sci. 2001; 69: 509 - 516.
55. Kataoka, K, Nohara R, Hosokawa R, Hirai T, Okuda K, Chen LG, Fujibayashi Y,Fujita M, Konishi J, Sasayama S: Myocardial lipid metabolism in compensated and advanced stages of heart failure: evaluation by canine pacing model with BMIPP. J Nucl Med 42 ;124-129
56. Miyamoto S, Goto Y, Fujita M, Daikoku S, Nagaya N, Yasuda S, Sumida H, Morii I, Itoh A, Miyazaki S, Nonogi H: Late reperfusion (6-24 hrs. after onset)improves left ventricular function in patients with acute myocardial infarction. Jpn Circ J 65 ;389-394
57. Inoko M, Fujita M, Nakae I, Tamaki S, Watanuki M, Hashimoto T, Konishi K: Effect of angiotensin-converting enzyme inhibition on sympathetic tone in patients with mild to moderate heart failure. Jpn Circ J 65 ; 395-398
58. Yamamoto T, Suto N, Okubo T, Mikuniya A, Hanada H, Yagihashi S, Fujita M,Okumura K: Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium. Jpn Circ J 65 ; 439-444
59. Chen L, Nohara R, Hirai T, Li X, Kataoka K, Hosokawa R, Masuda D, Fujita M, Taguchi T, Sasayama S: Effects of exercise training on myocardial fatty acid metabolism in rats with depressed cardiac function induced by transient ischemia. Jpn Circ J 65 ; 550-555
60. Miyamoto S, Fujita M, Sekiguchi H, Okano Y, Nagaya N, Ueda K, Tamaki S, Nohara R, Eiho S, Sasayama S: Effects of posture on cardiac autonomic nervous activity in patients with congestive heart failure. J Am Coll Cardiol 37 ; 1788-1793
61. Hirai T, Nohara R, Ogoh S, Chen LG, Kataoka K, Li XH, Fujita M, Matsumori A,Taguchi S, Sasayama S: Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. J Nucl Cardiol 8 ; 472-481
62. Pristipino C, Finocchiaro MC, Mongiardo R, Cianflone D, Sanna T, Maseri A, Beltrame JF, Hattori R, Fujita M, Sasayama S: Racial differences in coronary vasomotor response or selection bias. (Web Site Feature)Circulation 103:e35
63. Iwakura A, Tabata Y, Tamura N, Doi K, Nishimura K, Nakamura T, Shimizu Y, Fujita M, Komeda M: Gelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats. Circulation 104 (Suppl I)I325-I329

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